В поисках памяти

Результаты исследований приобретенного страха, указывающие на роль CREB-penpeccopa в подавлении долговременной памяти, а CREB-активатора — в ее усилении, опубликованы в статьях: J. С. P. Yin, J. S. Wallach, М. Del Vecchio, E. L. Wilder, H. Zhuo, W. G. Quinn & T. Tully, Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila,Cell 79 (1994): 49–58; J. C. P. Yin, M. Del Vecchio, H. Zhou & T. Tully, CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81 (1995): 107–115.

Данные о работе CREB-белков у пчел приведены в статье: D. Eisenhardt, A. Friedrich, N. Stollhoff, U. Muller, Н. Kress & R. Menzel, The AmCREB gene is an ortholog of the mammalian CREB/CREM family of transcription factors and encodes several splice variants in the honeybee brain,Insect Molecular Biol. 12 (2003): 373–382.

Данные о роли CREB-белков в приобретенном страхе у мышей приведены в статьях: Р. W. Frankland, S. A. Josselyn, S. G. Anag-n о star as et AL., Consolidation of CS and US representations in associative fear conditioning,Hippocampus 14 (2004): 557–569 и S. Kida, S. A. Josselyn, S. P. de Ortiz et al., CREB required for the stability of new and reactivated fear memories, Nature Neurosci.

Данные о роли CREB-белков в обучении у человека приведены в статьях: B. М. Alarcon, G. Malleret, К. Touzani, S. Vronskaya, S. Ishii, E. R. Kandel & A. Barco, Chromatin acetylation, memory, and LTP are impaired in СВР+/ — mice: A model for the cognitive deficit in Rubinstein-Taybi Syndrome and its amelioration,Neuron 42 (2004): 947–959.

Другие сведения, приведенные в этой главе, почерпнуты из следующих источников:

Bailey, С. Н., P. Montarolo, М. Chen, E. R. Kandel & S. Schacher. Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia.Neuron 9 (1992): 749–758.

Bartsch, D., A. Casadio, К. A. Karl, P. Serodio & E. R. Kandel. CREB-i encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.Cell 95 (1998): 211–223.

Bartsch, D., M. Ghirardi, A. Casadio, M. Giustetto, K. A. Karl, H. Zhu & E. R. Kandel. Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB-i and CREB-2.Cell 103 (2000): 595–608.

Casadio, А., К. C. Martin, M. Giustetto, H. Zhu, M. Chen, D. Bartsch, C. H. Bailey &E. R. Kandel. A transient neuron-wide form ofCREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.Cell 99 (1999)= 221–237.

Chain, D. G., A. Casadio, S. Schacher. A. N. Hegde. M. Valbrun, N. Yamamoto, A. L. Goldberg, D. Bartsch, E. R. Kandel & J. H. Schwartz. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia.Neuron 22 (1999): 147–156.

Dale, N. 81 E. R. Kandel. L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons,Proc. Natl. Acad. Sci. USA 90 (1993): 7163–7167.

Glanzman, D. L, E. R. Kandel &S. Schacher. Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons.Science 249 (1990): 799–802.

Kaang, B. K., E. R. Kandel & S. G. N. Grant. Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons.Neuron 10 (1993): 427–435.

Lorenz, K. Z. The Foundations of Ethology.New York: Springer Verlag, 1981.

Martin, K. C., D. Michael, J. C. Rose, M. Barad, A. Casadio, H. Zhu &E. R. Kandel. MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia.Neuron 18 (1997): 899–912.

Martin, К. C., A. Casadio, H. Zhu, E. Yaping, J. Rose, C. H. Bailey, M. Chen &E. R. Kandel. Synapse-specific transcription-dependent long-term facilitation of the sensory to motor neuron connection in Aplysia: A function for local protein synthesis in memory storage.Cell 91 (1997): 927–938.

Mayford, М., A. Barzilai, F. Keller, S. Schacher & E. R. Kandel. Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia.Science 256 (1992): 638–644.

Montarolo, P. G., P. Goelet, V. F. Castellucci, J. Morgan, E. R. Kandel & S. Schacher. A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia.Science 234 (1986): 1249–1254.

Montminy, M. R., K. A. Sevarino, J. A. Wagner, G. Mandel 8» R. H. Goodman. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.Proc. Natl. Acad. Sci. USA 83, no. 18 (1986): 6682–6686.

Prusiner, S. B. Prions. Les Prix Nobel/The Nobel Prizes, ed. Nobel Foundation.Stockholm: Almquist & Wiksell International, 1997.

Ray port, S. G. & S. Schacher. Synaptic plasticity in vitro: Cell culture of identified Aplysia neurons mediating short-term habituation and sensitization.J. Neurosci. 6 (1986): 759–763.

Schacher, S., V. F. Castellucci & E. R. Kandel. cAMP evokes longterm facilitation in Aplysia sensory neurons that requires new protein synthesis.Science 240 (1988): 1667–1669.

Si, К., M. Giustetto, A. Etkin, R. Hsu, A. M. Janisiewicz, М. C. Miniасi, J. H. Kim, H. Zhu &.E. R. Kandel. Aneuronaliso-form ofCPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia.Cell 115 (2003): 893–904.